NFC West
San Francisco 49ers
12-5
| Week | Opponent | Result |
|---|---|---|
| 1 |  at Seattle Seahawks | W 17-13 |
| 2 |  at New Orleans Saints | W 26-21 |
| 3 |  vs Arizona Cardinals | W 16-15 |
| 4 |  vs Jacksonville Jaguars | L 21-26 |
| 5 |  at Los Angeles Rams | W 26-23 |
| 6 |  at Tampa Bay Buccaneers | L 19-30 |
| 7 |  vs Atlanta Falcons | W 20-10 |
| 8 |  at Houston Texans | L 15-26 |
| 9 |  at New York Giants | W 34-24 |
| 10 | vs Los Angeles Rams | L 26-42 |
| 11 | at Arizona Cardinals | W 41-22 |
| 12 |  vs Carolina Panthers | W 20-9 |
| 13 |  at Cleveland Browns | W 26-8 |
| 15 |  vs Tennessee Titans | W 37-24 |
| 16 |  at Indianapolis Colts | W 48-27 |
| 17 |  vs Chicago Bears | W 42-38 |
| 18 | vs Seattle Seahawks | L 3-13 |