AFC East
Buffalo Bills
12-5
| Week | Opponent | Result |
|---|---|---|
| 1 |  vs Baltimore Ravens | W 41-40 |
| 2 |  at New York Jets | W 30-10 |
| 3 |  vs Miami Dolphins | W 31-21 |
| 4 |  vs New Orleans Saints | W 31-19 |
| 5 |  vs New England Patriots | L 20-23 |
| 6 |  at Atlanta Falcons | L 14-24 |
| 8 |  at Carolina Panthers | W 40-9 |
| 9 |  vs Kansas City Chiefs | W 28-21 |
| 10 | at Miami Dolphins | L 13-30 |
| 11 |  vs Tampa Bay Buccaneers | W 44-32 |
| 12 |  at Houston Texans | L 19-23 |
| 13 |  at Pittsburgh Steelers | W 26-7 |
| 14 |  vs Cincinnati Bengals | W 39-34 |
| 15 | at New England Patriots | W 35-31 |
| 16 |  at Cleveland Browns | W 23-20 |
| 17 |  vs Philadelphia Eagles | L 12-13 |
| 18 | vs New York Jets | W 35-8 |